Across TCGA pan-cancer cohorts, SNORD116-18 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SNORD116-18’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SNORD116-18 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD116-18 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, KIRC, and LUAD are the cancer types where SNORD116-18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD116-18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.469	<.001	6	view →
KIRC	All	III,IV	+0.164	.033	3	view →
LUAD	All	All	+0.267	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SNORD116-18 RNA expression & survival · all SNORD116-18 data types