Across TCGA pan-cancer cohorts, SNORD116-16 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SNORD116-16’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SNORD116-16 RNA is repressed in tumor relative to normal tissue. In most cancer types SNORD116-16 is over-expressed in tumor, although a few such as THCA and HNSC show the opposite, repressed pattern.

THCA, LIHC, and HNSC are the cancer types where SNORD116-16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD116-16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.544	<.001	5	view →
LIHC	Female	All	+0.147	.043	1	view →
HNSC	All	All	−0.108	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SNORD116-16 RNA expression & survival · all SNORD116-16 data types