Across TCGA pan-cancer cohorts, SNORD116-14 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated SNORD116-14 data layer.
The strongest signal is observed in mesothelioma (MESO), where higher SNORD116-14 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD116-14 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.
MESO, LUAD, and CESC are the cancer types where SNORD116-14 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.