Across TCGA pan-cancer cohorts, SNORD116-1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated SNORD116-1 data layer compared with 1 for mutation status.
The strongest signal is observed in mesothelioma (MESO), where higher SNORD116-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD116-1 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.
MESO, LIHC, and LUSC are the cancer types where SNORD116-1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.