Across TCGA pan-cancer cohorts, SNORD115-6 RNA is linked to patient survival in 2 of 34 cancer types, making it the most broadly survival-associated SNORD115-6 data layer compared with 1 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SNORD115-6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORD115-6 expression acts as an unfavorable survival marker.

SKCM and BLCA are the cancer types where SNORD115-6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	All	0.058	0.757	<.001	54	view →
BLCA	OS	Tertile	All	0.161	0.616	.039	18	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SNORD115-6 tumor-vs-normal RNA expression · all SNORD115-6 data types