Across TCGA patient cohorts, SNORD115-43 mutation is significantly associated with the RNA expression of many other genes, with 134 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SNORD115-43-associated genes across cancer lineages are PHOX2B-AS1, MFSD4BP1, and MRPS33P3. Each is linked with SNORD115-43 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNORD115-43-to-partner and partner-to-SNORD115-43 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNORD115-43→partner) and Y-score (partner→SNORD115-43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PHOX2B-AS1 →	+0.025	+4.900	<.001	.002	3	1
SKCM	MFSD4BP1 →	+0.031	+3.490	<.001	.002	3	1
SKCM	MRPS33P3 →	+0.091	+3.360	<.001	.006	3	1
SKCM	RNU6-991P →	+0.203	+4.408	<.001	.005	3	1
SKCM	RNU6-982P →	+0.315	+4.233	<.001	.001	3	1
SKCM	RNU6-1308P →	+0.135	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 134 associations by consensus.

Exploration

SNORD115-43 survival (RNA) · tumor vs normal (RNA) · all SNORD115-43 data types