Across TCGA pan-cancer cohorts, SNORD115-38 RNA is linked to patient survival in 5 of 34 cancer types, making it the most broadly survival-associated SNORD115-38 data layer compared with 2 for mutation status.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SNORD115-38 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORD115-38 expression acts as an unfavorable survival marker.
BLCA, LIHC, and KICH are the cancer types where SNORD115-38 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.