Across TCGA pan-cancer cohorts, SNORD115-31 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SNORD115-31 data layer compared with 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SNORD115-31 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD115-31 expression acts as an unfavorable survival marker.

LUSC and SKCM are the cancer types where SNORD115-31 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.202	0.778	<.001	27	view →
SKCM	DFS	Median	All	0.046	0.728	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SNORD115-31 tumor-vs-normal RNA expression · all SNORD115-31 data types