Across TCGA pan-cancer cohorts, SNORD115-3 RNA is linked to patient survival in 3 of 34 cancer types, making it the most broadly survival-associated SNORD115-3 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SNORD115-3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORD115-3 expression acts as an unfavorable survival marker.

HNSC, STAD, and KIRP are the cancer types where SNORD115-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.082	0.697	<.001	144	view →
STAD	DFS	Tertile	All	0.153	0.658	<.001	72	view →
KIRP	DFS	Tertile	All	0.016	0.920	<.001	36	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SNORD115-3 tumor-vs-normal RNA expression · all SNORD115-3 data types