Across TCGA pan-cancer cohorts, SNORD115-24 Mutation is linked to patient survival in 2 of 34 cancer types, making it the most broadly survival-associated SNORD115-24 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SNORD115-24 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD115-24 expression acts as an unfavorable survival marker.

LUAD and SKCM are the cancer types where SNORD115-24 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.147	0.709	<.001	24	view →
SKCM	OS	Median	II,III,IV	0.283	0.737	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SNORD115-24 tumor-vs-normal RNA expression · all SNORD115-24 data types