Across TCGA pan-cancer cohorts, SNORD115-2 RNA is linked to patient survival in 3 of 34 cancer types, making it the most broadly survival-associated SNORD115-2 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SNORD115-2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD115-2 expression acts as an unfavorable survival marker.

KIRP, STAD, and SARC are the cancer types where SNORD115-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.272	0.885	<.001	36	view →
STAD	OS	Tertile	All	0.142	0.730	<.001	18	view →
SARC	DFS	Tertile	All	0.095	0.632	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SNORD115-2 tumor-vs-normal RNA expression · all SNORD115-2 data types