Across TCGA pan-cancer cohorts, SNORD115-16 RNA is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SNORD115-16 data layer compared with 2 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SNORD115-16 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORD115-16 expression acts as an unfavorable survival marker.

BRCA are the cancer types where SNORD115-16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	All	0.329	0.903	<.001	72	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: SNORD115-16 tumor-vs-normal RNA expression · all SNORD115-16 data types