Across TCGA pan-cancer cohorts, SNORD115-16 Mutation is linked to patient survival in 2 of 34 cancer types, making it the most broadly survival-associated SNORD115-16 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SNORD115-16 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD115-16 expression acts as an unfavorable survival marker.

CESC and SKCM are the cancer types where SNORD115-16 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.091	0.875	<.001	48	view →
SKCM	OS	Median	II,III,IV	0.111	0.843	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SNORD115-16 tumor-vs-normal RNA expression · all SNORD115-16 data types