Across TCGA pan-cancer cohorts, SNORD115-12 RNA is linked to patient survival in 2 of 34 cancer types, making it the most broadly survival-associated SNORD115-12 data layer compared with 1 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SNORD115-12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD115-12 expression acts as an unfavorable survival marker.

LIHC and BRCA are the cancer types where SNORD115-12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	II,III,IV	0.051	0.696	<.001	36	view →
BRCA	DFS	Tertile	All	0.321	0.903	<.001	36	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SNORD115-12 tumor-vs-normal RNA expression · all SNORD115-12 data types