Across TCGA pan-cancer cohorts, SNORD115-12 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SNORD115-12 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SNORD115-12 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD115-12 expression acts as an unfavorable survival marker.

ESCA are the cancer types where SNORD115-12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.117	0.703	<.001	36	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: SNORD115-12 tumor-vs-normal RNA expression · all SNORD115-12 data types