Across TCGA pan-cancer cohorts, SNORD115-11 Mutation is linked to patient survival in 3 of 34 cancer types, making it the most broadly survival-associated SNORD115-11 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SNORD115-11 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD115-11 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

HNSC, CESC, and SKCM are the cancer types where SNORD115-11 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.162	0.685	.018	24	view →
CESC	OS	Median	All	0.227	0.798	.002	18	view →
SKCM	DFS	Median	II,III,IV	1.000	0.561	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SNORD115-11 tumor-vs-normal RNA expression · all SNORD115-11 data types