Across TCGA pan-cancer cohorts, SNORD114-22 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SNORD114-22 data layer compared with 9 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SNORD114-22 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SNORD114-22 expression acts as an unfavorable survival marker.

HNSC are the cancer types where SNORD114-22 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.184	0.685	.034	6	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: SNORD114-22 tumor-vs-normal RNA expression · all SNORD114-22 data types