Across TCGA pan-cancer cohorts, SNORD114-15 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SNORD114-15 data layer compared with 8 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SNORD114-15 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORD114-15 expression acts as an unfavorable survival marker.

SKCM and LUAD are the cancer types where SNORD114-15 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.192	0.737	.016	12	view →
LUAD	OS	Median	All	0.016	0.835	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SNORD114-15 tumor-vs-normal RNA expression · all SNORD114-15 data types