Across TCGA pan-cancer cohorts, SNORD114-1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SNORD114-1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SNORD114-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORD114-1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LUAD and KICH are the cancer types where SNORD114-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORD114-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.219	.047	1	view →
KICH	All	All	−0.200	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SNORD114-1 RNA expression & survival · all SNORD114-1 data types