SNORC

Across TCGA pan-cancer cohorts, SNORC RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SNORC data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SNORC RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORC expression acts as an unfavorable survival marker, although some lineages such as STAD and SCLC show a favorable association.

ACC, KIRC, and UCEC are the cancer types where SNORC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.214	0.693	<.001	135	view →
KIRC	DFS	Median	All	0.553	0.695	<.001	135	view →
UCEC	DFS	Quartile	III,IV	0.438	0.739	.005	50	view →
STAD	DFS	Quartile	All	0.782	0.564	<.001	43	view →
SCLC	OS	Tertile	All	1.000	0.410	.002	31	view →
LGG	OS	Tertile	All	0.949	0.858	.001	31	view →
COAD	OS	Quartile	II,III,IV	0.647	0.912	.001	30	view →
LUAD	DFS	Quartile	All	0.599	0.776	.005	23	view →
BRCA	OS	Median	All	0.943	0.905	.005	22	view →
PRAD	DFS	Median	All	0.895	0.968	<.001	20	view →
LUSC	DFS	Median	III,IV	0.270	0.497	.014	16	view →
HNSC	DFS	Median	IV	0.602	0.482	.017	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SNORC–ACC (DFS)

Open the ACC breakdown →