Across TCGA pan-cancer cohorts, SNORA77 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SNORA77’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SNORA77 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORA77 is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.
HNSC, KIRC, and BRCA are the cancer types where SNORA77 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORA77 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.