small nucleolar RNA, H/ACA box 66Genealiases: RNU66 · U66
Q-omics provides the consensus-scored SNORA66 profile across patient tissues and cancer cell-line models. SNORA66 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, SNORA66 is differentially expressed in 11, with the highest sampling consensus in COAD. Additionally, SNORA66 RNA expression shows 17,690 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, COAD, and UVM as cancer lineages where SNORA66 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SNORA66 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SNORA66 survival associations across molecular data types. SNORA66 RNA expression shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SNORA66 RNA expression–survival associations across cancer types. High SNORA66 expression shows unfavorable associations in KIRC, ACC and KIRP, but favorable associations in UCS, SKCM and GBM. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for SNORA66 RNA expression.
This table summarizes SNORA66 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for SNORA66. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SNORA66 shows higher tumor expression in COAD, READ, LUSC, HNSC, CHOL and BLCA. The COAD box plot shows higher SNORA66 RNA expression in tumor versus normal tissue (log2 FC = +1.124, t-test p < 0.001).
This table shows molecular features associated with SNORA66 in patient tissues and cancer cell lines. In patient samples, SNORA66 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
