Across TCGA pan-cancer cohorts, SNORA65 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SNORA65 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SNORA65 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORA65 expression acts as an unfavorable survival marker, although some lineages such as MESO and BLCA show a favorable association.

ACC, KIRC, and LAML are the cancer types where SNORA65 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.184	0.662	<.001	123	view →
KIRC	DFS	Quartile	II,III,IV	0.325	0.569	<.001	84	view →
LAML	DFS	Quartile	All	0.195	0.770	<.001	36	view →
LGG	DFS	Tertile	All	0.626	0.795	<.001	32	view →
MESO	DFS	Median	III,IV	0.495	0.256	<.001	32	view →
PRAD	DFS	Median	All	0.829	0.931	<.001	20	view →
BLCA	DFS	Median	All	0.573	0.452	.017	19	view →
READ	DFS	Tertile	II,III,IV	0.676	0.393	.014	18	view →
OV	OS	Median	II,III,IV	0.806	0.877	.011	18	view →
KIRP	DFS	Median	All	0.517	0.710	.004	13	view →
UVM	DFS	Median	All	0.287	0.667	.008	13	view →
UCS	DFS	Median	All	0.377	0.637	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

Exploration

Same gene, other analysis: SNORA65 tumor-vs-normal RNA expression · all SNORA65 data types