Across TCGA pan-cancer cohorts, SNORA5C RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SNORA5C data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SNORA5C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORA5C expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

KIRC, ACC, and UVM are the cancer types where SNORA5C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.514	0.700	<.001	89	view →
ACC	OS	Tertile	All	0.342	0.801	<.001	73	view →
UVM	DFS	Tertile	III,IV	0.244	0.922	.001	50	view →
LGG	OS	Tertile	All	0.731	0.872	<.001	45	view →
UCEC	DFS	Median	All	0.860	0.931	<.001	44	view →
COAD	OS	Median	II,III,IV	0.782	0.906	.003	36	view →
THCA	DFS	Quartile	II,III,IV	0.401	0.827	.004	35	view →
LUAD	DFS	Quartile	All	0.246	0.501	.008	34	view →
CESC	DFS	Quartile	All	0.667	0.851	.007	30	view →
KIRP	DFS	Tertile	IV	0.096	0.575	.004	30	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
STAD	DFS	Median	II,III,IV	0.341	0.683	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

Exploration

Same gene, other analysis: SNORA5C tumor-vs-normal RNA expression · all SNORA5C data types