SNORA58

Across TCGA pan-cancer cohorts, SNORA58 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SNORA58’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SNORA58 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNORA58 is over-expressed in tumor, although a few such as PAAD and THCA show the opposite, repressed pattern.

BLCA, HNSC, and LUSC are the cancer types where SNORA58 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORA58 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.663	.001	6	view →
HNSC	All	IV	+0.337	.030	5	view →
LUSC	All	II,III,IV	+0.467	<.001	4	view →
BRCA	All	II,III,IV	+0.240	.025	4	view →
LIHC	All	All	+0.095	.010	3	view →
PAAD	Female	All	−1.165	.001	2	view →
UCEC	All	II,III,IV	+0.412	.041	2	view →
THCA	All	III,IV	−0.300	.008	2	view →
COAD	All	All	+0.254	.029	2	view →
KIRC	Female	All	+0.223	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SNORA58–BLCA

Open the BLCA breakdown →