SNORA28

Across TCGA pan-cancer cohorts, SNORA28 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SNORA28 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SNORA28 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORA28 expression acts as an unfavorable survival marker, although some lineages such as OV and CHOL show a favorable association.

UVM, LGG, and OV are the cancer types where SNORA28 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.313	0.672	.003	48	view →
LGG	DFS	Median	All	0.775	0.889	<.001	33	view →
OV	DFS	Tertile	All	0.429	0.341	.014	30	view →
CHOL	DFS	Tertile	All	0.737	0.111	.002	18	view →
KIRC	DFS	Quartile	IV	0.293	0.657	.005	18	view →
CESC	DFS	Quartile	II,III,IV	0.642	0.852	.014	16	view →
COAD	DFS	Tertile	II,III,IV	0.311	0.669	.002	14	view →
KIRP	DFS	Median	All	0.445	0.735	.001	13	view →
LUSC	OS	Median	All	0.708	0.611	.019	12	view →
BRCA	OS	Quartile	III,IV	0.932	0.836	.015	11	view →
LAML	DFS	Quartile	All	0.492	0.292	.021	10	view →
MESO	OS	Tertile	III,IV	0.371	0.548	.030	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SNORA28–UVM (DFS)

Open the UVM breakdown →