Across TCGA pan-cancer cohorts, SNORA22 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SNORA22 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SNORA22 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SNORA22 expression acts as an unfavorable survival marker, although some lineages such as LUSC and UCEC show a favorable association.

KIRC, LGG, and READ are the cancer types where SNORA22 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	IV	0.189	0.507	<.001	62	view →
LGG	DFS	Median	All	0.663	0.813	<.001	51	view →
READ	DFS	Quartile	All	0.695	0.923	.001	42	view →
ACC	DFS	Median	All	0.445	0.776	.010	36	view →
KICH	DFS	Quartile	II,III,IV	0.460	1.000	.002	35	view →
CESC	DFS	Tertile	All	0.774	0.899	.004	24	view →
OV	OS	Tertile	All	0.791	0.893	.018	22	view →
LUSC	DFS	Median	All	0.471	0.306	.002	21	view →
UVM	DFS	Quartile	All	0.471	0.822	.020	15	view →
UCEC	DFS	Median	III,IV	0.847	0.741	.016	14	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	12	view →
BLCA	OS	Median	All	0.666	0.562	.020	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

Exploration

Same gene, other analysis: SNORA22 tumor-vs-normal RNA expression · all SNORA22 data types