Across TCGA pan-cancer cohorts, SNORA1B RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SNORA1B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SNORA1B RNA is repressed in tumor relative to normal tissue. In most cancer types SNORA1B is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and COAD are the cancer types where SNORA1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNORA1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−0.233	.009	2	view →
LUSC	Male	All	−0.194	.021	2	view →
COAD	All	All	+0.116	.032	2	view →
STAD	Male	All	+0.388	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SNORA1B RNA expression & survival · all SNORA1B data types