Across TCGA patient cohorts, SNN mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNN-associated genes across cancer lineages are EGFR_pY1173, Stathmin, and c-Met_pY1235. Each is linked with SNN in more than 1 cancer types. Because this analysis shows association rather than direction, both SNN-to-partner and partner-to-SNN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNN→partner) and Y-score (partner→SNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.088	+1.901	.017	.031	3	2
UCEC	Stathmin →	+0.259	+3.321	<.001	.010	3	2
UCEC	c-Met_pY1235 →	+0.072	+2.584	.037	.011	3	2
UCEC	eIF4G →	+0.400	+2.584	.005	.011	3	1
UCEC	ERK2 →	+0.319	+2.321	<.001	.034	3	1
UCEC	FOXO3a_pS318_S321 →	-0.161	-2.575	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

SNN survival (RNA) · tumor vs normal (RNA) · all SNN data types