SNHG6

Across TCGA pan-cancer cohorts, SNHG6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SNHG6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SNHG6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNHG6 is over-expressed in tumor, although a few such as BRCA and BLCA show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where SNHG6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNHG6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+1.071	<.001	12	view →
COAD	Female	II,III,IV	+1.648	<.001	11	view →
LIHC	Male	II,III,IV	+1.878	<.001	9	view →
HNSC	Male	IV	+1.035	<.001	8	view →
KIRP	All	III,IV	+0.908	<.001	8	view →
READ	All	All	+1.078	<.001	7	view →
STAD	All	II,III,IV	+0.802	.002	7	view →
THCA	All	II,III,IV	+0.523	.001	7	view →
CHOL	All	All	+2.610	<.001	5	view →
LUAD	Male	All	+0.663	<.001	5	view →
LUSC	All	All	+0.461	.001	5	view →
KICH	Male	IV	+2.460	.006	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SNHG6–KIRC

Open the KIRC breakdown →