SNED1

Across TCGA patient cohorts, SNED1 mutation is significantly associated with the RNA expression of many other genes, with 6,617 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNED1-associated genes across cancer lineages are ADAM33, ATP5MC3, and SEC13. Each is linked with SNED1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SNED1-to-partner and partner-to-SNED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM33 grouped by SNED1-low versus SNED1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNED1→partner) and Y-score (partner→SNED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADAM33 →	-0.610	-2.449	.005	.001	3	3
UCEC	ATP5MC3 →	+0.350	+2.012	.003	<.001	3	3
UCEC	SEC13 →	+0.309	+2.032	<.001	.001	3	3
UCEC	MRPS18C →	+0.404	+1.786	<.001	<.001	3	3
UCEC	CCDC51 →	+0.404	+1.765	<.001	<.001	3	3
UCEC	PTTG1 →	+0.569	+2.595	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,617 associations by consensus.

ADAM33 by SNED1 expression — UCEC

Explore this box plot interactively →