SNED1

Across TCGA patient cohorts, SNED1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNED1-associated genes across cancer lineages are PCNA, 4E-BP1_pT37_T46, and Caspase-7-cleavedD198. Each is linked with SNED1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SNED1-to-partner and partner-to-SNED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SNED1-low versus SNED1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNED1→partner) and Y-score (partner→SNED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.229	+2.099	<.001	<.001	3	3
UCEC	4E-BP1_pT37_T46 →	-0.291	-1.649	.008	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.699	+2.321	<.001	<.001	3	3
UCEC	eIF4E →	+0.207	+2.920	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.346	-1.514	.009	.014	3	2
UCEC	PDCD4 →	-0.472	-1.765	<.001	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

PCNA by SNED1 expression — UCEC

Explore this box plot interactively →