SNED1

Across TCGA cell cohorts, SNED1 mutation is significantly associated with the RNA expression of many other genes, with 375 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNED1-associated genes across cancer lineages are MIER1, PDE3A, and MYO6. Each is linked with SNED1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNED1-to-partner and partner-to-SNED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIER1 grouped by SNED1-low versus SNED1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNED1→partner) and Y-score (partner→SNED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MIER1 →	+0.580	+3.169	.002	.009	3	2
BLOOD_Leukemia	PDE3A →	+1.009	+3.700	<.001	.003	3	2
BLOOD_Leukemia	MYO6 →	+1.327	+3.199	.005	.007	3	2
OESOPHAGUS	TSPY10 →	+0.038	+4.017	.001	.007	3	1
LARGE_INTESTINE	CBY1 →	+0.728	+3.588	<.001	<.001	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.641	+3.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 375 associations by consensus.

MIER1 by SNED1 expression — LARGE_INTESTINE

Explore this box plot interactively →