Across TCGA pan-cancer cohorts, SND1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SND1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SND1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SND1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where SND1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.717	0.971	<.001	68	view →
LUAD	DFS	Quartile	All	0.953	0.800	.003	14	view →
PDAC	DFS	Median	III,IV	0.404	0.853	.023	6	view →
LSCC	DFS	Quartile	II,III,IV	0.539	0.894	.022	6	view →
HNSC	DFS	Median	IV	1.000	0.413	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SND1 tumor-vs-normal RNA expression · all SND1 data types