SNCA-AS1

Across TCGA pan-cancer cohorts, SNCA-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SNCA-AS1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SNCA-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SNCA-AS1 expression acts as an unfavorable survival marker, although some lineages such as ACC and PAAD show a favorable association.

UCEC, ACC, and READ are the cancer types where SNCA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	IV	0.238	0.690	<.001	54	view →
ACC	DFS	Median	II,III,IV	0.778	0.468	.001	51	view →
READ	DFS	Tertile	III,IV	0.480	0.818	.002	48	view →
KIRC	DFS	Tertile	All	0.540	0.681	.004	45	view →
KIRP	OS	Tertile	All	0.847	0.974	<.001	43	view →
PAAD	DFS	Median	All	0.425	0.196	<.001	42	view →
LGG	DFS	Median	All	0.499	0.323	<.001	29	view →
MESO	DFS	Tertile	All	0.188	0.618	.008	24	view →
BLCA	OS	Tertile	All	0.834	0.623	.015	22	view →
DLBC	OS	Tertile	II,III,IV	0.118	0.802	.025	21	view →
CESC	OS	Quartile	IV	0.227	0.611	.009	16	view →
SKCM	OS	Median	II,III,IV	0.802	0.877	.020	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SNCA-AS1–UCEC (OS)

Open the UCEC breakdown →