SNAPIN

Across TCGA pan-cancer cohorts, SNAPIN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SNAPIN data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SNAPIN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SNAPIN expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and COAD are the cancer types where SNAPIN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.508	0.296	<.001	69	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.842	.012	9	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
GBM	OS	Median	All	0.299	0.528	.022	3	view →
HNSC	DFS	Tertile	III,IV	1.000	0.911	.036	2	view →
CCRCC	DFS	Tertile	All	1.000	0.647	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SNAPIN–PDAC (DFS)

Open the PDAC breakdown →