SNAPC4

Across TCGA pan-cancer cohorts, SNAPC4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SNAPC4 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SNAPC4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SNAPC4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where SNAPC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.500	0.888	<.001	41	view →
LUAD	DFS	Median	III,IV	0.832	0.413	.004	21	view →
PDAC	OS	Tertile	All	0.676	0.992	.009	14	view →
UCEC	OS	Median	II,III,IV	1.000	0.653	.020	8	view →
GBM	OS	Median	All	0.571	0.270	.002	8	view →
LSCC	DFS	Median	III,IV	0.882	1.000	.049	1	view →
CCRCC	DFS	Median	All	0.793	1.000	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SNAPC4–HNSC (OS)

Open the HNSC breakdown →