SNAPC3

Across TCGA patient cohorts, SNAPC3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNAPC3-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and Mre11. Each is linked with SNAPC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNAPC3-to-partner and partner-to-SNAPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SNAPC3-low versus SNAPC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAPC3→partner) and Y-score (partner→SNAPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.400	-3.459	.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.184	-3.459	.002	.005	3	1
UCEC	Mre11 →	-0.094	-2.321	.029	.035	3	1
UCEC	MSH6 →	-0.522	-2.321	.001	.035	3	1
UCEC	PCNA →	+0.271	+2.321	.012	.035	3	1
UCEC	PI3K-p85 →	+0.306	+2.321	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by SNAPC3 expression — UCEC

Explore this box plot interactively →