SNAPC3

Across TCGA cell cohorts, SNAPC3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SNAPC3-associated genes across cancer lineages are LCE2B, PPIAL4F, and PPIAL4E. Each is linked with SNAPC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNAPC3-to-partner and partner-to-SNAPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE2B grouped by SNAPC3-low versus SNAPC3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAPC3→partner) and Y-score (partner→SNAPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LCE2B →	+0.040	+5.977	<.001	.001	3	1
SOFT_TISSUE	PPIAL4F →	+0.059	+4.930	<.001	.008	3	1
BLOOD_Lymphoma	PPIAL4E →	+0.283	+4.350	<.001	.005	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	MAGEB10 →	+0.072	+3.345	<.001	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

LCE2B by SNAPC3 expression — SOFT_TISSUE

Explore this box plot interactively →