SNAPC1

Across TCGA patient cohorts, SNAPC1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNAPC1-associated genes across cancer lineages are INPP4B, JNK2, and Ku80. Each is linked with SNAPC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNAPC1-to-partner and partner-to-SNAPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SNAPC1-low versus SNAPC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAPC1→partner) and Y-score (partner→SNAPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.327	-2.999	.030	.035	3	1
UCEC	JNK2 →	+0.241	+2.834	.009	.034	3	1
UCEC	Ku80 →	+0.257	+2.598	.019	.006	3	1
UCEC	Notch1 →	+0.173	+3.009	.008	.019	3	1
UCEC	p62 Lck ligand →	+0.367	+3.331	.015	.005	3	1
UCEC	PRAS40_pT246 →	+0.196	+1.887	.014	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

INPP4B by SNAPC1 expression — UCEC

Explore this box plot interactively →