SNAP47

Across TCGA patient cohorts, SNAP47 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNAP47-associated genes across cancer lineages are FoxM1, 14-3-3_beta, and Rab25. Each is linked with SNAP47 in more than 2 cancer types. Because this analysis shows association rather than direction, both SNAP47-to-partner and partner-to-SNAP47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SNAP47-low versus SNAP47-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAP47→partner) and Y-score (partner→SNAP47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.212	+1.807	.047	.027	3	3
UCEC	14-3-3_beta →	-0.123	-1.794	.003	.027	3	2
UCEC	Rab25 →	-0.400	-2.222	.003	.010	3	2
UCEC	Tuberin →	+0.354	+3.321	.001	.009	3	2
UCEC	eEF2 →	+0.473	+2.321	.001	.006	3	1
UCEC	EGFR_pY1068 →	-0.273	-2.321	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

FoxM1 by SNAP47 expression — UCEC

Explore this box plot interactively →