SNAP25

Across TCGA pan-cancer cohorts, SNAP25 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SNAP25’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SNAP25 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SNAP25 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, CCRCC, and LSCC are the cancer types where SNAP25 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNAP25 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−1.090	<.001	9	view →
CCRCC	Male	All	+0.952	<.001	5	view →
LSCC	All	II,III,IV	−0.359	<.001	4	view →
HNSC	Female	All	−0.270	.039	3	view →
PDAC	All	III,IV	−0.567	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SNAP25–COAD

Open the COAD breakdown →