SNAP23

Across TCGA pan-cancer cohorts, SNAP23 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SNAP23’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SNAP23 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SNAP23 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, HNSC, and LUAD are the cancer types where SNAP23 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNAP23 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.143	<.001	7	view →
HNSC	All	All	+0.135	.002	5	view →
LUAD	Female	II,III,IV	−0.223	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SNAP23–COAD

Open the COAD breakdown →