Across TCGA pan-cancer cohorts, SNAI3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SNAI3’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SNAI3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SNAI3 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.
KIRC, LUSC, and LUAD are the cancer types where SNAI3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SNAI3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.