SNAI1

Across TCGA patient cohorts, SNAI1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SNAI1-associated genes across cancer lineages are Tuberin, p70-S6K, and PRAS40_pT246. Each is linked with SNAI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNAI1-to-partner and partner-to-SNAI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by SNAI1-low versus SNAI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNAI1→partner) and Y-score (partner→SNAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.482	+2.817	.003	.036	3	1
UCEC	p70-S6K →	+0.304	+2.833	.009	.035	2	1
UCEC	PRAS40_pT246 →	+0.330	+2.820	.001	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Tuberin by SNAI1 expression — UCEC

Explore this box plot interactively →