SMYD5

Across TCGA patient cohorts, SMYD5 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,257 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMYD5-associated proteins across cancer lineages are MSH6, MSH2, and SF3B3. Each is linked with SMYD5 in more than 8 cancer types. Because this analysis shows association rather than direction, both SMYD5-to-partner and partner-to-SMYD5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMYD5 versus MSH6 in LSCC, with a Pearson correlation of 0.68.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD5→partner) and Y-score (partner→SMYD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MSH6 →	+0.654	+0.686	<.001	<.001	3	9
LSCC	MSH2 →	+0.579	+0.692	<.001	<.001	3	8
LSCC	SF3B3 →	+0.239	+0.702	<.001	<.001	3	7
BRCA	THOC1 →	+0.263	+0.391	<.001	<.001	3	7
LSCC	ADNP →	+0.336	+0.468	<.001	<.001	3	7
LSCC	CELF1 →	+0.316	+0.667	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,257 associations by consensus.

SMYD5 vs MSH6 — LSCC

Explore this scatter interactively →