SMYD5

Across TCGA patient cohorts, SMYD5 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMYD5-associated genes across cancer lineages are JNK_pT183_Y185, mTOR, and Notch1. Each is linked with SMYD5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMYD5-to-partner and partner-to-SMYD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SMYD5-low versus SMYD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD5→partner) and Y-score (partner→SMYD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.176	-2.321	.005	.005	3	2
UCEC	mTOR →	-0.224	-3.584	<.001	.002	3	2
UCEC	Notch1 →	+0.250	+2.662	<.001	<.001	2	3
UCEC	Stathmin →	+0.118	+1.700	.021	.042	3	2
UCEC	TIGAR →	+0.170	+1.792	.002	.008	3	2
UCEC	EGFR_pY1068 →	-0.191	-1.700	.042	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

JNK_pT183_Y185 by SMYD5 expression — UCEC

Explore this box plot interactively →