SMYD5

Across TCGA cell cohorts, SMYD5 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMYD5-associated genes across cancer lineages are ASPN, RANGRF, and DYNLL1. Each is linked with SMYD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMYD5-to-partner and partner-to-SMYD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASPN grouped by SMYD5-low versus SMYD5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD5→partner) and Y-score (partner→SMYD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASPN →	+0.035	+3.841	.002	<.001	3	1
LARGE_INTESTINE	RANGRF →	+0.607	+3.215	.006	.009	3	1
LARGE_INTESTINE	DYNLL1 →	+0.410	+3.064	.001	.009	3	1
LUNG_NSCLC_LUAD	CST11 →	+0.151	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	UMOD →	+0.006	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR7G2 →	+0.018	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ASPN by SMYD5 expression — LARGE_INTESTINE

Explore this box plot interactively →