Across TCGA patient cohorts, SMYD4 mutation is significantly associated with the RNA expression of many other genes, with 1,230 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMYD4-associated genes across cancer lineages are TRAJ58, TALDO1, and NCAPH2. Each is linked with SMYD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMYD4-to-partner and partner-to-SMYD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD4→partner) and Y-score (partner→SMYD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TRAJ58 →	+0.462	+3.466	.004	.005	3	3
UCEC	TALDO1 →	+0.665	+2.673	<.001	<.001	3	2
UCEC	NCAPH2 →	+0.584	+3.732	<.001	<.001	3	2
UCEC	RASSF1 →	+0.440	+3.584	<.001	.002	3	2
CESC	LINC02559 →	+0.749	+4.020	<.001	.009	3	2
CESC	MIR6815 →	+0.265	+4.020	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,230 associations by consensus.

Exploration

SMYD4 survival (RNA) · tumor vs normal (RNA) · all SMYD4 data types