Across TCGA patient cohorts, SMYD4 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMYD4-associated genes across cancer lineages are MEK1, p27_pT198, and eIF4G. Each is linked with SMYD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMYD4-to-partner and partner-to-SMYD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD4→partner) and Y-score (partner→SMYD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.648	+3.906	<.001	<.001	3	2
UCEC	p27_pT198 →	+0.102	+2.807	.028	.003	3	2
UCEC	eIF4G →	+0.280	+3.169	.039	.019	3	1
UCEC	p62 Lck ligand →	+0.482	+3.179	<.001	.010	3	1
UCEC	Rab11 →	-0.138	-2.115	.030	.019	3	1
UCEC	STAT3_pY705 →	-0.441	-2.459	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

SMYD4 survival (RNA) · tumor vs normal (RNA) · all SMYD4 data types